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Traxoprodil mesylate

CAS No. 188591-67-5

Traxoprodil mesylate( CP-101606 mesylate )

Catalog No. M12949 CAS No. 188591-67-5

A potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Traxoprodil mesylate
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM).
  • Description
    A potent, selective N-methyl-D-aspartate (NMDA) antagonist with selectivity for the NR2B subunit; potently protects cultured hippocampal neurons from glutamate toxicity (IC50=10 nM), dramatically reduces both the open dwell-time and frequency of channel opening of NR1/NR2B-containing receptors, but only modestly inhibits NR1/NR2A and NR1/NR2C channel activity; exhibits neuroprotective, analgesic, and anti-Parkinsonian effects in animal studies.Depression Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CP-101606 mesylate
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    iGluR
  • Research Area
    Neurological Disease
  • Indication
    Depression

Chemical Information

  • CAS Number
    188591-67-5
  • Formula Weight
    423.524
  • Molecular Formula
    C21H29NO6S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)(C3=CC=CC=C3)O.CS(=O)(=O)O
  • Chemical Name
    (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol mesylate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chenard BL,?et al. J Med Chem. 1995 Aug 4;38(16):3138-45. 2. Taniguchi K, et al. Br J Pharmacol. 1997 Nov;122(5):809-12. 3. Brimecombe JC, et al. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):11019-24. 4. Guscott MR, et al. Eur J Pharmacol. 2003 Aug 29;476(3):193-9.
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